Clinical Case Reports (Aug 2021)
Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
- Yu Takeuchi,
- Hidenao Noritake,
- Moe Matsumoto,
- Masahiro Umemura,
- Maho Yamashita,
- Kensuke Kitsugi,
- Shingo Takatori,
- Kazuyoshi Ohta,
- Jun Ito,
- Shin Shimoyama,
- Akira Kaysuya,
- Chiaki Maruyama,
- Kensuke Fukuchi,
- Satoshi Dohtan,
- Hiroe Sakata,
- Kazuhito Kawata
Affiliations
- Yu Takeuchi
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Hidenao Noritake
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Moe Matsumoto
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Masahiro Umemura
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Maho Yamashita
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Kensuke Kitsugi
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Shingo Takatori
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Kazuyoshi Ohta
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Jun Ito
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Shin Shimoyama
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- Akira Kaysuya
- Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan
- Chiaki Maruyama
- Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan
- Kensuke Fukuchi
- Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan
- Satoshi Dohtan
- Department of Hematology Hamamatsu University School of Medicine Hamamatsu Japan
- Hiroe Sakata
- Department of Dentistry and Oral and Maxillofacial Surgery Hamamatsu University School of Medicine Hamamatsu Japan
- Kazuhito Kawata
- Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan
- DOI
- https://doi.org/10.1002/ccr3.4696
- Journal volume & issue
-
Vol. 9,
no. 8
pp. n/a – n/a
Abstract
Abstract This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
Keywords
