Nature Communications (Jun 2022)

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

  • Jia Wei,
  • Philippa C. Matthews,
  • Nicole Stoesser,
  • Ian Diamond,
  • Ruth Studley,
  • Emma Rourke,
  • Duncan Cook,
  • John I. Bell,
  • John N. Newton,
  • Jeremy Farrar,
  • Alison Howarth,
  • Brian D. Marsden,
  • Sarah Hoosdally,
  • E. Yvonne Jones,
  • David I. Stuart,
  • Derrick W. Crook,
  • Tim E. A. Peto,
  • A. Sarah Walker,
  • David W. Eyre,
  • Koen B. Pouwels,
  • The COVID-19 Infection Survey team

Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9


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The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.