Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Yumeng Wang; Jingxian Sun; Keying Zhu; Danjie Wang; Xiaoqiang Zhao; Hongyu Zhang; Shuai Wu; Yanqing Wang; Jun Wang

doi:10.1186/s12974-023-02764-3

Journal of Neuroinflammation (Mar 2023)

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Yumeng Wang,
Jingxian Sun,
Keying Zhu,
Danjie Wang,
Xiaoqiang Zhao,
Hongyu Zhang,
Shuai Wu,
Yanqing Wang,
Jun Wang

Affiliations

Yumeng Wang: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Jingxian Sun: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Keying Zhu: Department of Clinical Neuroscience, Karolinska Institute, Center for Molecular Medicine, Karolinska University Hospital
Danjie Wang: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Xiaoqiang Zhao: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Hongyu Zhang: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Shuai Wu: Department of Neurology, Zhongshan Hospital, Fudan University
Yanqing Wang: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University
Jun Wang: Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University

DOI: https://doi.org/10.1186/s12974-023-02764-3
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 19

Abstract

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Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination. Microglial AhR deficiency causes myelin debris accumulation and impairs phagocytic function. Microglial AhR mediates phagocytosis of microglia via SYK.

Published in Journal of Neuroinflammation

ISSN: 1742-2094 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://jneuroinflammation.biomedcentral.com/

About the journal

Abstract

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