Nature Communications (Nov 2019)
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation
- Qingsheng Liu,
- Alan Chiu,
- Long-Hai Wang,
- Duo An,
- Monica Zhong,
- Alexandra M. Smink,
- Bart J. de Haan,
- Paul de Vos,
- Kevin Keane,
- Andreas Vegge,
- Esther Y. Chen,
- Wei Song,
- Wendy F. Liu,
- James Flanders,
- Claude Rescan,
- Lars Groth Grunnet,
- Xi Wang,
- Minglin Ma
Affiliations
- Qingsheng Liu
- Department of Biological and Environmental Engineering, Cornell University
- Alan Chiu
- Department of Biological and Environmental Engineering, Cornell University
- Long-Hai Wang
- Department of Biological and Environmental Engineering, Cornell University
- Duo An
- Department of Biological and Environmental Engineering, Cornell University
- Monica Zhong
- Department of Biological and Environmental Engineering, Cornell University
- Alexandra M. Smink
- Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen
- Bart J. de Haan
- Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen
- Paul de Vos
- Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen
- Kevin Keane
- Stem Cell Biology, Novo Nordisk A/S
- Andreas Vegge
- Diabetes Research, Novo Nordisk A/S
- Esther Y. Chen
- Department of Biomedical Engineering, University of California Irvine
- Wei Song
- Department of Biological and Environmental Engineering, Cornell University
- Wendy F. Liu
- Department of Biomedical Engineering, University of California Irvine
- James Flanders
- Department of Clinical Sciences, Cornell University
- Claude Rescan
- Stem Cell Pharmacology, Novo Nordisk A/S
- Lars Groth Grunnet
- Stem Cell Pharmacology, Novo Nordisk A/S
- Xi Wang
- Department of Biological and Environmental Engineering, Cornell University
- Minglin Ma
- Department of Biological and Environmental Engineering, Cornell University
- DOI
- https://doi.org/10.1038/s41467-019-13238-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Cellular overgrowth and fibrosis in the foreign body response can compromise the function of transplanted cells. Here, the authors report on the zwitterionically modified alginates for the encapsulation of cells to reduce cellular overgrowth and demonstrate application in mice, dogs and pigs.
