Clinical, Cosmetic and Investigational Dermatology (Jul 2020)
308-nm Excimer Laser Plus Platelet-Rich Plasma for Treatment of Stable Vitiligo: A Prospective, Randomized Case–Control Study
Abstract
Yanyan Deng,1,2 Jia Li,3 Gaoyun Yang1 1Department of Dermatology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, People’s Republic of China; 2Department of Dermatology, The Second People’s Hospital of Changzhi, Changzhi 046000, People’s Republic of China; 3Department of Dermatology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan 030009, People’s Republic of ChinaCorrespondence: Gaoyun YangDepartment of Dermatology, Beijing Friendship Hospital Affiliated to Capital Medical University, No. 95 Yong’an Road, West City District, Beijing 100050, People’s Republic of ChinaTel +86-13520713158Email [email protected]: 308-nm excimer laser has a confirmed treatment effect on vitiligo. Platelet-rich plasma (PRP) is an autologous preparation which contains a variety of growth factors. The effect of 308-nm excimer laser combined with PRP on vitiligo has been rarely reported. This study investigated the effect of PRP combined with 308-nm excimer laser on stable vitiligo.Patients and Methods: A total of 60 patients with localized stable vitiligo who received treatment at Beijing Friendship Hospital and Xi’an Vitiligo Specialist Hospital between May 2019 and January 2020 were consecutively enrolled. They were equally randomized into three groups according to different treatment methods: intradermal PRP injection (group I), 308-nm excimer laser alone (group II), and 308-nm excimer laser plus PRP injection (group III). All treatments lasted for 3 months. At 3 months after treatment, clinical assessments were performed in terms of the visual analogue scale (VAS) score, repigmentation response and side effects.Results: The VAS scores showed significant differences among the three groups (P< 0.001), with the highest score in group III, followed by group II and then group I. Repigmentation responses also showed significant differences among the groups (P< 0.001), and the best effect was observed in group III. No side effects were reported in any of the groups.Conclusion: The effect of PRP combined with 308-nm excimer laser on stable vitiligo is significantly better than that of PRP and 308-nm excimer laser alone. It is safe and satisfactorily tolerant.Keywords: vitiligo, laser, combined therapy, visual analogue scale, repigmentation
