Бюллетень сибирской медицины (Apr 2009)

The role of cytokines in redox-dependent regulation of apoptosis

  • O. Ye. Chechina,
  • A. K. Biktasova,
  • Ye. V. Sazonova,
  • O. B. Zhukova,
  • T. S. Prokhorenko,
  • I. V. Krat,
  • N. Yu. Chasovskikh,
  • V. V. Novitsky,
  • N. V. Ryazantseva

DOI
https://doi.org/10.20538/1682-0363-2009-2-67-71
Journal volume & issue
Vol. 8, no. 2
pp. 67 – 71

Abstract

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Research of influence of recombinant tumor necrosis factor alpha, interleukin-2 and interleukin-4 in vitro on the apoptosis of lymphocytes is performed. It is revealed that a proapoptotic effect of these cytokines is dose-dependent and is realized with the assistance of reactive oxygen species and mitochondrias.

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