Nature Communications (Jan 2019)

Promotion of homology-directed DNA repair by polyamines

  • Chih-Ying Lee,
  • Guan-Chin Su,
  • Wen-Yen Huang,
  • Min-Yu Ko,
  • Hsin-Yi Yeh,
  • Geen-Dong Chang,
  • Sung-Jan Lin,
  • Peter Chi

DOI
https://doi.org/10.1038/s41467-018-08011-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation of RAD51-mediated homologous DNA pairing and strand exchange.