Pifu-xingbing zhenliaoxue zazhi (Oct 2022)
Comparison of inflammation-related clinical characteristics and laboratory parameters among different types of psoriasis
Abstract
Objective This study aimed to investigate the differences in inflammation-related clinical features and laboratory parameters, including fever, white blood cell count, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), among patients with psoriasis vulgaris (PV), erythrodermic psoriasis (EP), and generalized pustular psoriasis (GPP). Methods This single-center retrospective study included 163 psoriatic inpatients from our department in the past 10 years. Pearson's chi-square test was used to analyze demographic data, body temperature and blood cell counts. One-way ANOVA and Dunns POST test were used to analyze gaussian distribution data, while Kruskal-Wallis test was used for analysis of non-Gaussian distribution data. Results In term of age distribution, the proportion of patients under 30 years old in GPP group was significantly higher than that in EP and PV groups. The rates of fever on the first day of admission were significantly higher in EP (66.67%) and GPP (77.19%) groups than in PV group (10.34%). Likewise, higher proportion of patients in EP and GPP displayed high leukocyte count (>10×109/L) than that in PV group (43.75% and 73.68% vs 12.07% and 3.45%). Moreover, more patients in GPP group had high leukocyte count than that in the EP group. Similarly, proportion of patients with high neutrophil count (>7.5×109/L) was also significantly higher in EP (33.33%) and GPP (66.67%) groups than in PV group. Again, proportion of patients with high neutrophil count was higher in the GPP group than in EP group. Furthermore, high monocyte count (>1×109/L) was found in 20.83% of patients in EP group and 36.84% in GPP group, which both were significantly higher than that in the PV group. Additionally, 81.25% of patients in EP group and 87.72% in GPP group displayed increased CRP, which both were higher than that in PV group (17.24%). Finally, increased ESR was found in 83.33% of patients in EP group and 84.21% in GPP group (both P<0.05 vs 15.52% in PV group). Conclusions Compared with PV, patients with EP and GPP are more likely to develop inflammation associated features such as fever and elevation in inflammatory markers, including leukocytes, neutrophils, monocytes, CRP and ESR. The proportion of patients with elevated leukocytes and neutrophils in GPP patients is higher than that in EP patients. Different types of psoriasis show significant differences in the inflammation-associated clinical characteristics and laboratory parameters, suggesting that the underlying pathogenesis may be different, and different treatment regimens should be employed, accordingly.
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