A CASE REPORT OF PSEUDOMEMBRANOUS COLITIS, NOT ASSOCIATED WITH PRIOR ANTIMICROBIAL DRUGS TREATMENT

Abstract

Clostridium difficile associated colitis /CDAC/ is an inflammatory bowel disease with infectious etiology and specific endoscopic and histological data. It is the most common cause of acute diarrhea syndrome, occurring during hospitalization. CDAC usually appears after treatment with antimicrobial agents , such as Clindamycin, Glycopeptides, Fluoroquinolones, II-nd and III-rd gen. Cephalosporins . Sometimes CDAC is triggered by other factors – nonsteroid anti – inflammatory drugs (NSAIDs), chemotherapy drugs, ulcerative colitis, Crohn’s disease and others. The typical complaints of the patients with CDAC are : abdominal pain, diarrhea, fever, and leukocytosis. Since pseudomembranous colitis is associated with C. difficile infection, stool testing and empirical antibiotic treatment should be initiated when suspected. Тhe case report is about 83 years old woman with clinically, laboratory, endoscopic and histological data typical for pseudomembranous colitis, without a history of previous antibiotic therapy . The case shows that the CDAC may be atypical and the disease should be well – known and expected, especially in immunocompromised or comorbid people over 65 years old with history for NSAIDs or chemotherapy drugs treatment, with acute diarrhea.

Keywords

• clostridium difficile
• pseudomembranous colitis
• antimicrobial therapy