Chromatin accessibility analysis reveals regulatory dynamics and therapeutic relevance of Vogt-Koyanagi-Harada disease

Wen Shi; Jinguo Ye; Zhuoxing Shi; Caineng Pan; Qikai Zhang; Yuheng Lin; Yuanting Luo; Wenru Su; Yingfeng Zheng; Yizhi Liu

doi:10.1038/s42003-022-03430-9

Communications Biology (May 2022)

Chromatin accessibility analysis reveals regulatory dynamics and therapeutic relevance of Vogt-Koyanagi-Harada disease

Wen Shi,
Jinguo Ye,
Zhuoxing Shi,
Caineng Pan,
Qikai Zhang,
Yuheng Lin,
Yuanting Luo,
Wenru Su,
Yingfeng Zheng,
Yizhi Liu

Affiliations

Wen Shi: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Jinguo Ye: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Zhuoxing Shi: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Caineng Pan: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Qikai Zhang: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Yuheng Lin: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Yuanting Luo: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Wenru Su: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Yingfeng Zheng: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Yizhi Liu: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science

DOI: https://doi.org/10.1038/s42003-022-03430-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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Single-cell RNA-sequencing and chromatin accessibility analysis reveal transcriptomic and epigenomic changes between healthy patients and those affected by the systemic autoimmune disorder Vogt-Koyanagi-Harada disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal