Nature Communications (Nov 2022)

A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice

  • Jie Sun,
  • Ming Wang,
  • Yaqi Zhong,
  • Xuan Ma,
  • Shimin Sun,
  • Chenzhong Xu,
  • Linyuan Peng,
  • Guo Li,
  • Liting Zhang,
  • Zuojun Liu,
  • Ding Ai,
  • Baohua Liu

DOI
https://doi.org/10.1038/s41467-022-34801-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Monitoring the aging process in vivo is challenging. Here the authors generate a Glb1 +/m‒Glb1-2A-mCherry (GAC) reporter mouse model, where the GAC signal is consistently correlated with established biomarkers of cellular senescence, cardiac hypertrophy and shortened lifespan, which may prove helpful for studies developing anti-aging interventions.