Case Reports in Oncology (Mar 2024)

Solitary Clear Cell Renal Cell Carcinoma Metastasis to the Eyelid: A Case Report

  • Ognjen Zrinšćak,
  • Armin Kasumović,
  • Iva Krolo,
  • Renata Ivekovic,
  • Maja Malenica Ravlić,
  • Igor Tomašković,
  • Zoran Vatavuk

DOI
https://doi.org/10.1159/000537860
Journal volume & issue
Vol. 17, no. 1
pp. 477 – 483

Abstract

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Introduction: This study is a case of solitary clear cell renal cell carcinoma (ccRCC) eyelid metastasis in a 66-year-old man as the first sign of a primary tumor. ccRCC usually spreads to the lungs, mediastinum, bones, liver, and brain, while ocular metastases are rare. Case Presentation: Solitary metastasis presented as a solid mass in the central third of the upper eyelid, which has been growing for 3 weeks. Treatment included tumor removal and blepharoplasty. Histopathological examination showed metastasis of clear cell renal carcinoma. A thorough examination revealed a primary tumor on the lower pole of the right kidney. A right nephrectomy was performed, and histopathology showed ccRCC. Postoperative examinations showed no signs of local or systemic disease. Sunitinib malate was administered to the patient. Conclusion: The eyelid metastasis in this case was still solitary and had been discovered before the existence of the primary tumor was known. Ocular metastasis of renal carcinoma is a rare initial manifestation of the disease and therefore requires a multidisciplinary approach in the treatment of these patients.

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