Nature Communications (Jun 2018)

miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling

  • Jeffrey Lam,
  • Marion van den Bosch,
  • Joanna Wegrzyn,
  • Jeremy Parker,
  • Rawa Ibrahim,
  • Kate Slowski,
  • Linda Chang,
  • Sergio Martinez-Høyer,
  • Gianluigi Condorelli,
  • Mark Boldin,
  • Yu Deng,
  • Patricia Umlandt,
  • Megan Fuller,
  • Aly Karsan

DOI
https://doi.org/10.1038/s41467-018-04831-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Myelodysplastic syndrome (MDS) is characterized by altered hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation and reduction of miR-143 and miR-145 in some subtypes. Here the authors show that miR-143/145 loss leads to HSC depletion, HPC expansion and malignancy through Dab2 -mediated TGFβ pathway activation.