Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Zongyang Lv; Lingmin Yuan; James H. Atkison; Katelyn M. Williams; Ramir Vega; E. Hampton Sessions; Daniela B. Divlianska; Christopher Davies; Yuan Chen; Shaun K. Olsen

doi:10.1038/s41467-018-07015-1

Nature Communications (Dec 2018)

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Zongyang Lv,
Lingmin Yuan,
James H. Atkison,
Katelyn M. Williams,
Ramir Vega,
E. Hampton Sessions,
Daniela B. Divlianska,
Christopher Davies,
Yuan Chen,
Shaun K. Olsen

Affiliations

Zongyang Lv: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina
Lingmin Yuan: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina
James H. Atkison: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina
Katelyn M. Williams: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina
Ramir Vega: Department of Molecular Medicine, Beckman Research Institute of City of Hope
E. Hampton Sessions: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
Daniela B. Divlianska: Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
Christopher Davies: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina
Yuan Chen: Department of Molecular Medicine, Beckman Research Institute of City of Hope
Shaun K. Olsen: Department of Biochemistry & Molecular Biology and Hollings Cancer Center, Medical University of South Carolina

DOI: https://doi.org/10.1038/s41467-018-07015-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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