Nature Communications (Jul 2020)
Accelerated single cell seeding in relapsed multiple myeloma
- Heather J. Landau,
- Venkata Yellapantula,
- Benjamin T. Diamond,
- Even H. Rustad,
- Kylee H. Maclachlan,
- Gunes Gundem,
- Juan Medina-Martinez,
- Juan Arango Ossa,
- Max F. Levine,
- Yangyu Zhou,
- Rajya Kappagantula,
- Priscilla Baez,
- Marc Attiyeh,
- Alvin Makohon-Moore,
- Lance Zhang,
- Eileen M. Boyle,
- Cody Ashby,
- Patrick Blaney,
- Minal Patel,
- Yanming Zhang,
- Ahmet Dogan,
- David J. Chung,
- Sergio Giralt,
- Oscar B. Lahoud,
- Jonathan U. Peled,
- Michael Scordo,
- Gunjan Shah,
- Hani Hassoun,
- Neha S. Korde,
- Alexander M. Lesokhin,
- Sydney Lu,
- Sham Mailankody,
- Urvi Shah,
- Eric Smith,
- Malin L. Hultcrantz,
- Gary A. Ulaner,
- Frits van Rhee,
- Gareth J. Morgan,
- Ola Landgren,
- Elli Papaemmanuil,
- Christine Iacobuzio-Donahue,
- Francesco Maura
Affiliations
- Heather J. Landau
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Venkata Yellapantula
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Benjamin T. Diamond
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Even H. Rustad
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Kylee H. Maclachlan
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gunes Gundem
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Juan Medina-Martinez
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Juan Arango Ossa
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Max F. Levine
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Yangyu Zhou
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Rajya Kappagantula
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Priscilla Baez
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Marc Attiyeh
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Alvin Makohon-Moore
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Lance Zhang
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Eileen M. Boyle
- NYU Perlmutter Cancer Center
- Cody Ashby
- Myeloma Center, University of Arkansas for Medical Sciences
- Patrick Blaney
- NYU Perlmutter Cancer Center
- Minal Patel
- Center for Hematological Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Yanming Zhang
- Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ahmet Dogan
- Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center
- David J. Chung
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Sergio Giralt
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Oscar B. Lahoud
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Jonathan U. Peled
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Michael Scordo
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gunjan Shah
- Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Hani Hassoun
- Department of Medicine, Weill Cornell Medical College
- Neha S. Korde
- Department of Medicine, Weill Cornell Medical College
- Alexander M. Lesokhin
- Department of Medicine, Weill Cornell Medical College
- Sydney Lu
- Department of Medicine, Weill Cornell Medical College
- Sham Mailankody
- Department of Medicine, Weill Cornell Medical College
- Urvi Shah
- Department of Medicine, Weill Cornell Medical College
- Eric Smith
- Department of Medicine, Weill Cornell Medical College
- Malin L. Hultcrantz
- Department of Medicine, Weill Cornell Medical College
- Gary A. Ulaner
- Department of Radiology, Memorial Sloan Kettering Cancer Center
- Frits van Rhee
- Myeloma Center, University of Arkansas for Medical Sciences
- Gareth J. Morgan
- NYU Perlmutter Cancer Center
- Ola Landgren
- Department of Medicine, Weill Cornell Medical College
- Elli Papaemmanuil
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Christine Iacobuzio-Donahue
- Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Francesco Maura
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-17459-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
In multiple myeloma, disease progresses via seeding to different anatomic sites and clonal expansion. Here, utilising autopsy material, the authors show that systemic seeding accelerates at relapse following treatment.
