Nature Communications (Aug 2018)

Genomic patterns of progression in smoldering multiple myeloma

  • Niccolò Bolli,
  • Francesco Maura,
  • Stephane Minvielle,
  • Dominik Gloznik,
  • Raphael Szalat,
  • Anthony Fullam,
  • Inigo Martincorena,
  • Kevin J. Dawson,
  • Mehmet Kemal Samur,
  • Jorge Zamora,
  • Patrick Tarpey,
  • Helen Davies,
  • Mariateresa Fulciniti,
  • Masood A. Shammas,
  • Yu Tzu Tai,
  • Florence Magrangeas,
  • Philippe Moreau,
  • Paolo Corradini,
  • Kenneth Anderson,
  • Ludmil Alexandrov,
  • David C. Wedge,
  • Herve Avet-Loiseau,
  • Peter Campbell,
  • Nikhil Munshi

DOI
https://doi.org/10.1038/s41467-018-05058-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but trajectories of evolution can vary from patient to patient.