Modeling and simulation of phototransduction cascade in vertebrate rod photoreceptors

Abstract

Abstract Background The activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes. Methods In this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Simulation was performed to validate developed model structure. Results The developed model structure could fit experimental data with small error. Conclusions The result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors.

Keywords

• Phototransduction
• ERG a wave
• Rod
• Photoreceptor
• Kinetic model structure