CryoEM structure and assembly mechanism of a bacterial virus genome gatekeeper

Igor Orlov; Stéphane Roche; Sandrine Brasilès; Natalya Lukoyanova; Marie-Christine Vaney; Paulo Tavares; Elena V. Orlova

doi:10.1038/s41467-022-34999-8

Nature Communications (Nov 2022)

CryoEM structure and assembly mechanism of a bacterial virus genome gatekeeper

Igor Orlov,
Stéphane Roche,
Sandrine Brasilès,
Natalya Lukoyanova,
Marie-Christine Vaney,
Paulo Tavares,
Elena V. Orlova

Affiliations

Igor Orlov: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, Université de Strasbourg
Stéphane Roche: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Sandrine Brasilès: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Natalya Lukoyanova: Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College
Marie-Christine Vaney: Institut Pasteur, Université Paris Cité, CNRS UMR3569, Unité de Virologie Structurale
Paulo Tavares: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Elena V. Orlova: Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College

DOI: https://doi.org/10.1038/s41467-022-34999-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Numerous viruses use a portal system for dsDNA entry and exit from their capsid. Here the authors report the atomic structure of phage SPP1 portal DNA gatekeeper and its mechanism of assembly. They also identify evolution breakpoints between different tailed bacteriophages morphotypes and herpesviruses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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