Pain Research and Management (Jan 2025)

Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake

  • Zihan Liu,
  • Anan Liu,
  • Jing Chen,
  • Jing-Rui Chai,
  • Panwen Liu,
  • Ru-Feng Ye,
  • Jing-Gen Liu,
  • Yu-Jun Wang

DOI
https://doi.org/10.1155/prm/5656675
Journal volume & issue
Vol. 2025

Abstract

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Conclusion: These results suggest that, in neuropathic pain, the analgesic effects of dezocine are mediated through KOR and MOR activation, together with norepinephrine reuptake inhibition (NRI) and serotonin reuptake inhibition. In contrast, in cancer pain, KOR and MOR activation and NRI are involved in mediating the analgesic effect of dezocine. This study, along with previous data, enhances our understanding of the potential clinical utility of dezocine and elucidates its mechanisms of action in chronic pain management.