TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression

Zhongxia Yu; Lijuan Wang; Jing Zhao; Hui Song; Chunyuan Zhao; Wei Zhao; Mutian Jia

doi:10.1038/s42003-022-03911-x

Communications Biology (Sep 2022)

TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression

Zhongxia Yu,
Lijuan Wang,
Jing Zhao,
Hui Song,
Chunyuan Zhao,
Wei Zhao,
Mutian Jia

Affiliations

Zhongxia Yu: Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Lijuan Wang: Pathology Tissue Bank, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Jing Zhao: Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Hui Song: Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Chunyuan Zhao: Department of Cell Biology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Wei Zhao: Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Mutian Jia: Department of Immunology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University

DOI: https://doi.org/10.1038/s42003-022-03911-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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TOB1 is identified as an interferon regulatory factor 3 (IRF3) binding partner that operates as a negative feedback inhibitor of IFNβ in toll-like receptor and cytosolic nucleic acid receptor sensing pathways.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal