Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases

Jingxuan Han; Jingxuan Han; Lailiu Luo; Lailiu Luo; Yicheng Wang; Yicheng Wang; Shourong Wu; Shourong Wu; Shourong Wu; Vivi Kasim; Vivi Kasim; Vivi Kasim

doi:10.3389/fphar.2022.974775

Frontiers in Pharmacology (Aug 2022)

Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases

Jingxuan Han,
Jingxuan Han,
Lailiu Luo,
Lailiu Luo,
Yicheng Wang,
Yicheng Wang,
Shourong Wu,
Shourong Wu,
Shourong Wu,
Vivi Kasim,
Vivi Kasim,
Vivi Kasim

Affiliations

Jingxuan Han: The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
Jingxuan Han: State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China
Lailiu Luo: The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
Lailiu Luo: State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China
Yicheng Wang: The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
Yicheng Wang: State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China
Shourong Wu: The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
Shourong Wu: State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China
Shourong Wu: The 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing, China
Vivi Kasim: The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
Vivi Kasim: State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China
Vivi Kasim: The 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing, China

DOI: https://doi.org/10.3389/fphar.2022.974775
Journal volume & issue: Vol. 13

Abstract

Read online

Rhodiola is an ancient wild plant that grows in rock areas in high-altitude mountains with a widespread habitat in Asia, Europe, and America. From empirical belief to research studies, Rhodiola has undergone a long history of discovery, and has been used as traditional medicine in many countries and regions for treating high-altitude sickness, anoxia, resisting stress or fatigue, and for promoting longevity. Salidroside, a phenylpropanoid glycoside, is the main active component found in all species of Rhodiola. Salidroside could enhance cell survival and angiogenesis while suppressing oxidative stress and inflammation, and thereby has been considered a potential compound for treating ischemia and ischemic injury. In this article, we highlight the recent advances in salidroside in treating ischemic diseases, such as cerebral ischemia, ischemic heart disease, liver ischemia, ischemic acute kidney injury and lower limb ischemia. Furthermore, we also discuss the pharmacological functions and underlying molecular mechanisms. To our knowledge, this review is the first one that covers the protective effects of salidroside on different ischemia-related disease.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

Keywords