Assessment of antiulcer activity in crude extract of Paeonia mascula subsp. atlantica (Coss.) Greuter & Burdet

Abstract

Peptic ulcer disease poses a critical health risk, leading to considerable morbidity and mortality. It arises from an imbalance between aggressive factors that damage the stomach’s mucosal lining and protective components that safeguard it. Traditional plant–based remedies have gained traction as potential alternatives to conventional drugs. This experiment aimed to assess the anti–ulcer action of the crude extract of Paeonia mascula through two in vivo tests using male Wistar rats. The preventive test involved inducing acute gastric lesions, while the therapeutic test involved treating the lesions with crude extract and in vitro quantifying stomach parameters such as gastric volume, pH, total acidity, pepsin activity, and ulcer index. The results illustrated a noteworthy reduction in ulcer index in preventive and healing tests. These findings suggest that the extract has an anti–ulcerogenic effect by suppressing acid secretion and reducing gastric injuries.

Keywords

• Antiulcer
• crude extract
• Paeonia mascula
• preventive
• curative