Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

A. E. Yuzhalin; A. N. Gordon-Weeks; M. L. Tognoli; K. Jones; B. Markelc; R. Konietzny; R. Fischer; A. Muth; E. O’Neill; P. R. Thompson; P. J. Venables; B. M. Kessler; S. Y. Lim; R. J. Muschel

doi:10.1038/s41467-018-07306-7

Nature Communications (Nov 2018)

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

A. E. Yuzhalin,
A. N. Gordon-Weeks,
M. L. Tognoli,
K. Jones,
B. Markelc,
R. Konietzny,
R. Fischer,
A. Muth,
E. O’Neill,
P. R. Thompson,
P. J. Venables,
B. M. Kessler,
S. Y. Lim,
R. J. Muschel

Affiliations

A. E. Yuzhalin: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
A. N. Gordon-Weeks: Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital
M. L. Tognoli: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
K. Jones: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
B. Markelc: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
R. Konietzny: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
R. Fischer: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
A. Muth: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
E. O’Neill: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
P. R. Thompson: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
P. J. Venables: Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford
B. M. Kessler: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
S. Y. Lim: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
R. J. Muschel: CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford

DOI: https://doi.org/10.1038/s41467-018-07306-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of citrullination could serve as therapeutic avenue in the treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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