In situ reprogramming of gut bacteria by oral delivery

Bryan B. Hsu; Isaac N. Plant; Lorena Lyon; Frances M. Anastassacos; Jeffrey C. Way; Pamela A. Silver

doi:10.1038/s41467-020-18614-2

Nature Communications (Oct 2020)

In situ reprogramming of gut bacteria by oral delivery

Bryan B. Hsu,
Isaac N. Plant,
Lorena Lyon,
Frances M. Anastassacos,
Jeffrey C. Way,
Pamela A. Silver

Affiliations

Bryan B. Hsu: Department of Biological Sciences, Virginia Tech
Isaac N. Plant: Department of Systems Biology, Harvard Medical School
Lorena Lyon: Department of Systems Biology, Harvard Medical School
Frances M. Anastassacos: Wyss Institute for Biologically Inspired Engineering, Harvard University
Jeffrey C. Way: Department of Systems Biology, Harvard Medical School
Pamela A. Silver: Department of Systems Biology, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-18614-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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