Nature Communications (Jun 2020)
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division
- Martina Bonucci,
- Nicolas Kuperwasser,
- Serena Barbe,
- Vonda Koka,
- Delphine de Villeneuve,
- Chi Zhang,
- Nishit Srivastava,
- Xiaoying Jia,
- Matthew P. Stokes,
- Frank Bienaimé,
- Virginie Verkarre,
- Jean Baptiste Lopez,
- Fanny Jaulin,
- Marco Pontoglio,
- Fabiola Terzi,
- Benedicte Delaval,
- Matthieu Piel,
- Mario Pende
Affiliations
- Martina Bonucci
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Nicolas Kuperwasser
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Serena Barbe
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Vonda Koka
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Delphine de Villeneuve
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Chi Zhang
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Nishit Srivastava
- Institut Curie, PSL Research University, CNRS, UMR 144
- Xiaoying Jia
- Cell Signaling Technology INC, 3 Trask Lane
- Matthew P. Stokes
- Cell Signaling Technology INC, 3 Trask Lane
- Frank Bienaimé
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Virginie Verkarre
- Université de Paris, PARCC, INSERM, Equipe Labellisée par la Ligue contre le Cancer
- Jean Baptiste Lopez
- INSERM U-981, Gustave Roussy
- Fanny Jaulin
- INSERM U-981, Gustave Roussy
- Marco Pontoglio
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Fabiola Terzi
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- Benedicte Delaval
- CRBM, CNRS, Univ. Montpellier, Centrosome, cilia and pathologies Lab, 1919 Route de Mende
- Matthieu Piel
- Institut Curie, PSL Research University, CNRS, UMR 144
- Mario Pende
- Institut Necker-Enfants Malades, 14 rue Maria Helena Vieira Da Silva
- DOI
- https://doi.org/10.1038/s41467-020-16978-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.
