Nature Communications (May 2020)
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
- Sean P. Polster,
- Anukriti Sharma,
- Ceylan Tanes,
- Alan T. Tang,
- Patricia Mericko,
- Ying Cao,
- Julián Carrión-Penagos,
- Romuald Girard,
- Janne Koskimäki,
- Dongdong Zhang,
- Agnieszka Stadnik,
- Sharbel G. Romanos,
- Seán B. Lyne,
- Robert Shenkar,
- Kimberly Yan,
- Cornelia Lee,
- Amy Akers,
- Leslie Morrison,
- Myranda Robinson,
- Atif Zafar,
- Kyle Bittinger,
- Helen Kim,
- Jack A. Gilbert,
- Mark L. Kahn,
- Le Shen,
- Issam A. Awad
Affiliations
- Sean P. Polster
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Anukriti Sharma
- Department of Surgery, The University of Chicago
- Ceylan Tanes
- Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Alan T. Tang
- Department of Medicine and Cardiovascular Institute, University of Pennsylvania
- Patricia Mericko
- Department of Medicine and Cardiovascular Institute, University of Pennsylvania
- Ying Cao
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Julián Carrión-Penagos
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Romuald Girard
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Janne Koskimäki
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Dongdong Zhang
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Agnieszka Stadnik
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Sharbel G. Romanos
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Seán B. Lyne
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Robert Shenkar
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Kimberly Yan
- Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research
- Cornelia Lee
- Angioma Alliance
- Amy Akers
- Angioma Alliance
- Leslie Morrison
- Department of Neurology, University of New Mexico, 1 University of New Mexico
- Myranda Robinson
- Department of Neurology, University of New Mexico, 1 University of New Mexico
- Atif Zafar
- Department of Neurology, University of New Mexico, 1 University of New Mexico
- Kyle Bittinger
- Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Helen Kim
- Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research
- Jack A. Gilbert
- Department of Surgery, The University of Chicago
- Mark L. Kahn
- Department of Medicine and Cardiovascular Institute, University of Pennsylvania
- Le Shen
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- Issam A. Awad
- Section of Neurosurgery, Department of Surgery, The University of Chicago
- DOI
- https://doi.org/10.1038/s41467-020-16436-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Gut microbiome has been linked to cavernous angioma (CA), a common vascular disease, but the role in humans remains unclear. Here, the authors combine 16S rRNA sequencing and shotgun metagenomics to profile the microbiome in a large cohort of human subjects with and without CA, and among subjects with different CA clinical features.
