Nature Communications (Sep 2021)
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
Abstract
Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.