The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Yeo Jin Shin; Ki-Sun Kwon; Ki-Sun Kwon; Ki-Sun Kwon; Yousin Suh; Yousin Suh; Kwang-Pyo Lee; Kwang-Pyo Lee

doi:10.3389/fmolb.2023.1308274

Frontiers in Molecular Biosciences (Jan 2024)

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Yeo Jin Shin,
Ki-Sun Kwon,
Ki-Sun Kwon,
Ki-Sun Kwon,
Yousin Suh,
Yousin Suh,
Kwang-Pyo Lee,
Kwang-Pyo Lee

Affiliations

Yeo Jin Shin: Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Ki-Sun Kwon: Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Ki-Sun Kwon: Department of Bioscience, KRIBB School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea
Ki-Sun Kwon: Aventi Inc., Daejeon, Republic of Korea
Yousin Suh: Department of Obstetrics and Gynecology, Columbia University, New York, NY, United States
Yousin Suh: Department of Genetics and Development, Columbia University, New York, NY, United States
Kwang-Pyo Lee: Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
Kwang-Pyo Lee: Department of Bioscience, KRIBB School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea

DOI: https://doi.org/10.3389/fmolb.2023.1308274
Journal volume & issue: Vol. 10

Abstract

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Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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