Gastric hyperplastic polyps: immunohistochemical characteristic of proliferation and apoptosis

Abstract

Aim. In order to research proliferation and apoptosis immunohistochemical study of expression of Ki-67 and Caspase-3 inbiopsies of 42 gastric hyperplastic polyps was conducted. Methods and results. It was found that gastric hyperplastic polyps are characterized by middle expression level of Ki-67 (2,4±0,09 points) and extremely low expression level of Casp-3 (13,6±0,392 points) in surface foveolar cells, and also low expression level of Ki-67 (0,7±0,04 points) and middle expression level of Casp-3 (61,4±9,487 points) in cells of lamina propria. In hyperplastic polyps with middle and high epithelial dysplasia expression level of Ki-67 inepithelial cells and cells of lamina propria increases. Conclusion. These results demonstrate the leading role of cell proliferation in progression of gastric hyperplastic polyps.

Keywords

• Stomach Diseases
• Polyps
• Cell Proliferation
• Apoptosis