Phytol-derived novel isoprenoid immunostimulants

Abstract

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This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior in many respects to a number of commercial adjuvants.

Keywords

• Inflammasome
• activation of innate immunity
• antibody and CTL response
• cytokine microenvironment
• immunostimulants
• Isoprenoid adjuvants