1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer

• Stefani Spranger,
• Rakesh K Jain,
• Kim Nguyen,
• Arjun Bhutkar,
• Ivy Chen,
• Dig Bijay Mahat,
• Heena Kumra,
• Emily Metcalf,
• Sarah Castro,
• William W Ho,
• Brandon Sullivan,
• Leon K Yim,
• Vikash Chauhan,
• Hernandez Moura Silva,
• Phillip A Sharp

Affiliations

Stefani Spranger

Rakesh K Jain

1Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Kim Nguyen

3Massachusetts Institute of Technology, Cambridge, MA, USA

Arjun Bhutkar

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Ivy Chen

2Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Dig Bijay Mahat

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Heena Kumra

2Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Emily Metcalf

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Sarah Castro

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

William W Ho

2Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Brandon Sullivan

4Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA

Leon K Yim

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Vikash Chauhan

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Hernandez Moura Silva

4Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA

Phillip A Sharp

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA