Endothelial Unc5B controls blood-brain barrier integrity

Kevin Boyé; Luiz Henrique Geraldo; Jessica Furtado; Laurence Pibouin-Fragner; Mathilde Poulet; Doyeun Kim; Bryce Nelson; Yunling Xu; Laurent Jacob; Nawal Maissa; Dritan Agalliu; Lena Claesson-Welsh; Susan L. Ackerman; Anne Eichmann

doi:10.1038/s41467-022-28785-9

Nature Communications (Mar 2022)

Endothelial Unc5B controls blood-brain barrier integrity

Kevin Boyé,
Luiz Henrique Geraldo,
Jessica Furtado,
Laurence Pibouin-Fragner,
Mathilde Poulet,
Doyeun Kim,
Bryce Nelson,
Yunling Xu,
Laurent Jacob,
Nawal Maissa,
Dritan Agalliu,
Lena Claesson-Welsh,
Susan L. Ackerman,
Anne Eichmann

Affiliations

Kevin Boyé: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Luiz Henrique Geraldo: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Jessica Furtado: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Laurence Pibouin-Fragner: Université de Paris, INSERM, PARCC
Mathilde Poulet: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine
Doyeun Kim: OliX pharmaceuticals
Bryce Nelson: Department of Pharmacology, Cancer Biology Institute, Yale University School of Medicine
Yunling Xu: Université de Paris, INSERM, PARCC
Laurent Jacob: Université de Paris, INSERM, PARCC
Nawal Maissa: Université de Paris, INSERM, PARCC
Dritan Agalliu: Departments of Neurology and Pathology and Cell Biology, Columbia University Irving Medical Center
Lena Claesson-Welsh: Department of Immunology, Genetics and Pathology, Uppsala University
Susan L. Ackerman: Division of Biological Sciences Section of Neurobiology and Department of Cellular and Molecular Medicine, University of California San Diego and Howard Hughes Medical Institute
Anne Eichmann: Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-28785-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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