Nature Communications (Nov 2022)
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants
- Songhai Tian,
- Xiaozhe Xiong,
- Ji Zeng,
- Siyu Wang,
- Benjamin Jean-Marie Tremblay,
- Peng Chen,
- Baohua Chen,
- Min Liu,
- Pengsheng Chen,
- Kuanwei Sheng,
- Daniel Zeve,
- Wanshu Qi,
- David T. Breault,
- César Rodríguez,
- Ralf Gerhard,
- Rongsheng Jin,
- Andrew C. Doxey,
- Min Dong
Affiliations
- Songhai Tian
- Department of Urology, Boston Children’s Hospital
- Xiaozhe Xiong
- Department of Urology, Boston Children’s Hospital
- Ji Zeng
- Department of Urology, Boston Children’s Hospital
- Siyu Wang
- Department of Urology, Boston Children’s Hospital
- Benjamin Jean-Marie Tremblay
- Department of Biology, Cheriton School of Computer Science, and Waterloo Centre for Microbial Research, University of Waterloo
- Peng Chen
- Department of Physiology and Biophysics, School of Medicine, University of California Irvine
- Baohua Chen
- Department of Physiology and Biophysics, School of Medicine, University of California Irvine
- Min Liu
- Department of Urology, Boston Children’s Hospital
- Pengsheng Chen
- Department of Urology, Boston Children’s Hospital
- Kuanwei Sheng
- Wyss Institute for Bioinspired Engineering, Harvard University
- Daniel Zeve
- Division of Endocrinology, Boston Children’s Hospital
- Wanshu Qi
- Division of Endocrinology, Boston Children’s Hospital
- David T. Breault
- Division of Endocrinology, Boston Children’s Hospital
- César Rodríguez
- Faculty of Microbiology & CIET, University of Costa Rica
- Ralf Gerhard
- Institute of Toxicology, Hannover Medical School
- Rongsheng Jin
- Department of Physiology and Biophysics, School of Medicine, University of California Irvine
- Andrew C. Doxey
- Department of Biology, Cheriton School of Computer Science, and Waterloo Centre for Microbial Research, University of Waterloo
- Min Dong
- Department of Urology, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-022-33964-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with C. difficile infection. Here, Tian et al. show that several TcdB subtypes do not recognize the established FZD receptors, and identify a different host protein (TFPI) as a receptor for subtypes TcdB4 and TcdB10.
