International Journal of Nanomedicine (Jul 2022)

Nanobiotechnology: Applications in Chronic Wound Healing

  • Jiang T,
  • Li Q,
  • Qiu J,
  • Chen J,
  • Du S,
  • Xu X,
  • Wu Z,
  • Yang X,
  • Chen Z,
  • Chen T

Journal volume & issue
Vol. Volume 17
pp. 3125 – 3145

Abstract

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Tao Jiang,1,* Qianyun Li,1,* Jinmei Qiu,2 Jing Chen,1 Shuang Du,2 Xiang Xu,1 Zihan Wu,1 Xiaofan Yang,1 Zhenbing Chen,1 Tongkai Chen2 1Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenbing Chen, Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, People’s Republic of China, Tel +86 13871103730, Email [email protected] Tongkai Chen, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, 510405, People’s Republic of China, Tel +86 20 36585707, Email [email protected]: Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.Keywords: nanobiotechnology, chronic wound healing, scaffold systems, cell-carrying systems, stimuli-responsive systems

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