LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields

Donovan M. Ashby; Stan B. Floresco; Anthony G. Phillips; Alexander McGirr; Jeremy K. Seamans; Yu Tian Wang

doi:10.1038/s41467-020-20317-7

Nature Communications (Jan 2021)

LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields

Donovan M. Ashby,
Stan B. Floresco,
Anthony G. Phillips,
Alexander McGirr,
Jeremy K. Seamans,
Yu Tian Wang

Affiliations

Donovan M. Ashby: Hotchkiss Brain Institute, University of Calgary
Stan B. Floresco: Djavad Mowafaghian Centre for Brain Health, University of British Columbia
Anthony G. Phillips: Djavad Mowafaghian Centre for Brain Health, University of British Columbia
Alexander McGirr: Hotchkiss Brain Institute, University of Calgary
Jeremy K. Seamans: Djavad Mowafaghian Centre for Brain Health, University of British Columbia
Yu Tian Wang: Djavad Mowafaghian Centre for Brain Health, University of British Columbia

DOI: https://doi.org/10.1038/s41467-020-20317-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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