Nature Communications (Dec 2024)
Genomic perspective on the bacillus causing paratyphoid B fever
- Jane Hawkey,
- Lise Frézal,
- Alicia Tran Dien,
- Anna Zhukova,
- Derek Brown,
- Marie Anne Chattaway,
- Sandra Simon,
- Hidemasa Izumiya,
- Patricia I. Fields,
- Niall De Lappe,
- Lidia Kaftyreva,
- Xuebin Xu,
- Junko Isobe,
- Dominique Clermont,
- Elisabeth Njamkepo,
- Yukihiro Akeda,
- Sylvie Issenhuth-Jeanjean,
- Mariia Makarova,
- Yanan Wang,
- Martin Hunt,
- Brent M. Jenkins,
- Magali Ravel,
- Véronique Guibert,
- Estelle Serre,
- Zoya Matveeva,
- Laëtitia Fabre,
- Martin Cormican,
- Min Yue,
- Baoli Zhu,
- Masatomo Morita,
- Zamin Iqbal,
- Carolina Silva Nodari,
- Maria Pardos de la Gandara,
- François-Xavier Weill
Affiliations
- Jane Hawkey
- Department of Infectious Diseases, School of Translational Medicine, Monash University
- Lise Frézal
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Alicia Tran Dien
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Anna Zhukova
- Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub
- Derek Brown
- Scottish Microbiology Reference Laboratories (SMiRL)
- Marie Anne Chattaway
- Gastrointestinal Bacteria Reference Unit (GBRU), United Kingdom Health Security Agency
- Sandra Simon
- Unit of Enteropathogenic Bacteria and Legionella (FG11)/National Reference Centre for Salmonella and Other Bacterial Enteric Pathogens, Robert Koch-Institute
- Hidemasa Izumiya
- Department of Bacteriology I, National Institute of Infectious Diseases
- Patricia I. Fields
- Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention
- Niall De Lappe
- National Salmonella, Shigella and Listeria Reference Laboratory, Galway University Hospitals
- Lidia Kaftyreva
- Pasteur Institute of St Petersburg
- Xuebin Xu
- Department of Microbiology, Shanghai Municipal Centre for Disease Control and Prevention
- Junko Isobe
- Department of Bacteriology, Toyama Institute of Health
- Dominique Clermont
- Institut Pasteur, Université Paris Cité, Collection of Institut Pasteur (CIP)
- Elisabeth Njamkepo
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Yukihiro Akeda
- Department of Bacteriology I, National Institute of Infectious Diseases
- Sylvie Issenhuth-Jeanjean
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Mariia Makarova
- Pasteur Institute of St Petersburg
- Yanan Wang
- International Joint Research Centre for National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University
- Martin Hunt
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Brent M. Jenkins
- Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention
- Magali Ravel
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Véronique Guibert
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Estelle Serre
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Zoya Matveeva
- Pasteur Institute of St Petersburg
- Laëtitia Fabre
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Martin Cormican
- National Salmonella, Shigella and Listeria Reference Laboratory, Galway University Hospitals
- Min Yue
- Department of Veterinary Medicine, Zhejiang University College of Animal Sciences
- Baoli Zhu
- CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Masatomo Morita
- Department of Bacteriology I, National Institute of Infectious Diseases
- Zamin Iqbal
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Carolina Silva Nodari
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- Maria Pardos de la Gandara
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- François-Xavier Weill
- Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques
- DOI
- https://doi.org/10.1038/s41467-024-54418-4
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 17
Abstract
Abstract Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.
