Nature Communications (Jan 2021)

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

  • Vasiliki Lagou,
  • Reedik Mägi,
  • Jouke- Jan Hottenga,
  • Harald Grallert,
  • John R. B. Perry,
  • Nabila Bouatia-Naji,
  • Letizia Marullo,
  • Denis Rybin,
  • Rick Jansen,
  • Josine L. Min,
  • Antigone S. Dimas,
  • Anna Ulrich,
  • Liudmila Zudina,
  • Jesper R. Gådin,
  • Longda Jiang,
  • Alessia Faggian,
  • Amélie Bonnefond,
  • Joao Fadista,
  • Maria G. Stathopoulou,
  • Aaron Isaacs,
  • Sara M. Willems,
  • Pau Navarro,
  • Toshiko Tanaka,
  • Anne U. Jackson,
  • May E. Montasser,
  • Jeff R. O’Connell,
  • Lawrence F. Bielak,
  • Rebecca J. Webster,
  • Richa Saxena,
  • Jeanette M. Stafford,
  • Beate St Pourcain,
  • Nicholas J. Timpson,
  • Perttu Salo,
  • So-Youn Shin,
  • Najaf Amin,
  • Albert V. Smith,
  • Guo Li,
  • Niek Verweij,
  • Anuj Goel,
  • Ian Ford,
  • Paul C. D. Johnson,
  • Toby Johnson,
  • Karen Kapur,
  • Gudmar Thorleifsson,
  • Rona J. Strawbridge,
  • Laura J. Rasmussen-Torvik,
  • Tõnu Esko,
  • Evelin Mihailov,
  • Tove Fall,
  • Ross M. Fraser,
  • Anubha Mahajan,
  • Stavroula Kanoni,
  • Vilmantas Giedraitis,
  • Marcus E. Kleber,
  • Günther Silbernagel,
  • Julia Meyer,
  • Martina Müller-Nurasyid,
  • Andrea Ganna,
  • Antti-Pekka Sarin,
  • Loic Yengo,
  • Dmitry Shungin,
  • Jian’an Luan,
  • Momoko Horikoshi,
  • Ping An,
  • Serena Sanna,
  • Yvonne Boettcher,
  • N. William Rayner,
  • Ilja M. Nolte,
  • Tatijana Zemunik,
  • Erik van Iperen,
  • Peter Kovacs,
  • Nicholas D. Hastie,
  • Sarah H. Wild,
  • Stela McLachlan,
  • Susan Campbell,
  • Ozren Polasek,
  • Olga Carlson,
  • Josephine Egan,
  • Wieland Kiess,
  • Gonneke Willemsen,
  • Johanna Kuusisto,
  • Markku Laakso,
  • Maria Dimitriou,
  • Andrew A. Hicks,
  • Rainer Rauramaa,
  • Stefania Bandinelli,
  • Barbara Thorand,
  • Yongmei Liu,
  • Iva Miljkovic,
  • Lars Lind,
  • Alex Doney,
  • Markus Perola,
  • Aroon Hingorani,
  • Mika Kivimaki,
  • Meena Kumari,
  • Amanda J. Bennett,
  • Christopher J. Groves,
  • Christian Herder,
  • Heikki A. Koistinen,
  • Leena Kinnunen,
  • Ulf de Faire,
  • Stephan J. L. Bakker,
  • Matti Uusitupa,
  • Colin N. A. Palmer,
  • J. Wouter Jukema,
  • Naveed Sattar,
  • Anneli Pouta,
  • Harold Snieder,
  • Eric Boerwinkle,
  • James S. Pankow,
  • Patrik K. Magnusson,
  • Ulrika Krus,
  • Chiara Scapoli,
  • Eco J. C. N. de Geus,
  • Matthias Blüher,
  • Bruce H. R. Wolffenbuttel,
  • Michael A. Province,
  • Goncalo R. Abecasis,
  • James B. Meigs,
  • G. Kees Hovingh,
  • Jaana Lindström,
  • James F. Wilson,
  • Alan F. Wright,
  • George V. Dedoussis,
  • Stefan R. Bornstein,
  • Peter E. H. Schwarz,
  • Anke Tönjes,
  • Bernhard R. Winkelmann,
  • Bernhard O. Boehm,
  • Winfried März,
  • Andres Metspalu,
  • Jackie F. Price,
  • Panos Deloukas,
  • Antje Körner,
  • Timo A. Lakka,
  • Sirkka M. Keinanen-Kiukaanniemi,
  • Timo E. Saaristo,
  • Richard N. Bergman,
  • Jaakko Tuomilehto,
  • Nicholas J. Wareham,
  • Claudia Langenberg,
  • Satu Männistö,
  • Paul W. Franks,
  • Caroline Hayward,
  • Veronique Vitart,
  • Jaakko Kaprio,
  • Sophie Visvikis-Siest,
  • Beverley Balkau,
  • David Altshuler,
  • Igor Rudan,
  • Michael Stumvoll,
  • Harry Campbell,
  • Cornelia M. van Duijn,
  • Christian Gieger,
  • Thomas Illig,
  • Luigi Ferrucci,
  • Nancy L. Pedersen,
  • Peter P. Pramstaller,
  • Michael Boehnke,
  • Timothy M. Frayling,
  • Alan R. Shuldiner,
  • Patricia A. Peyser,
  • Sharon L. R. Kardia,
  • Lyle J. Palmer,
  • Brenda W. Penninx,
  • Pierre Meneton,
  • Tamara B. Harris,
  • Gerjan Navis,
  • Pim van der Harst,
  • George Davey Smith,
  • Nita G. Forouhi,
  • Ruth J. F. Loos,
  • Veikko Salomaa,
  • Nicole Soranzo,
  • Dorret I. Boomsma,
  • Leif Groop,
  • Tiinamaija Tuomi,
  • Albert Hofman,
  • Patricia B. Munroe,
  • Vilmundur Gudnason,
  • David S. Siscovick,
  • Hugh Watkins,
  • Cecile Lecoeur,
  • Peter Vollenweider,
  • Anders Franco-Cereceda,
  • Per Eriksson,
  • Marjo-Riitta Jarvelin,
  • Kari Stefansson,
  • Anders Hamsten,
  • George Nicholson,
  • Fredrik Karpe,
  • Emmanouil T. Dermitzakis,
  • Cecilia M. Lindgren,
  • Mark I. McCarthy,
  • Philippe Froguel,
  • Marika A. Kaakinen,
  • Valeriya Lyssenko,
  • Richard M. Watanabe,
  • Erik Ingelsson,
  • Jose C. Florez,
  • Josée Dupuis,
  • Inês Barroso,
  • Andrew P. Morris,
  • Inga Prokopenko,
  • Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)

DOI
https://doi.org/10.1038/s41467-020-19366-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.