Nature Communications (Jan 2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
- Vasiliki Lagou,
- Reedik Mägi,
- Jouke- Jan Hottenga,
- Harald Grallert,
- John R. B. Perry,
- Nabila Bouatia-Naji,
- Letizia Marullo,
- Denis Rybin,
- Rick Jansen,
- Josine L. Min,
- Antigone S. Dimas,
- Anna Ulrich,
- Liudmila Zudina,
- Jesper R. Gådin,
- Longda Jiang,
- Alessia Faggian,
- Amélie Bonnefond,
- Joao Fadista,
- Maria G. Stathopoulou,
- Aaron Isaacs,
- Sara M. Willems,
- Pau Navarro,
- Toshiko Tanaka,
- Anne U. Jackson,
- May E. Montasser,
- Jeff R. O’Connell,
- Lawrence F. Bielak,
- Rebecca J. Webster,
- Richa Saxena,
- Jeanette M. Stafford,
- Beate St Pourcain,
- Nicholas J. Timpson,
- Perttu Salo,
- So-Youn Shin,
- Najaf Amin,
- Albert V. Smith,
- Guo Li,
- Niek Verweij,
- Anuj Goel,
- Ian Ford,
- Paul C. D. Johnson,
- Toby Johnson,
- Karen Kapur,
- Gudmar Thorleifsson,
- Rona J. Strawbridge,
- Laura J. Rasmussen-Torvik,
- Tõnu Esko,
- Evelin Mihailov,
- Tove Fall,
- Ross M. Fraser,
- Anubha Mahajan,
- Stavroula Kanoni,
- Vilmantas Giedraitis,
- Marcus E. Kleber,
- Günther Silbernagel,
- Julia Meyer,
- Martina Müller-Nurasyid,
- Andrea Ganna,
- Antti-Pekka Sarin,
- Loic Yengo,
- Dmitry Shungin,
- Jian’an Luan,
- Momoko Horikoshi,
- Ping An,
- Serena Sanna,
- Yvonne Boettcher,
- N. William Rayner,
- Ilja M. Nolte,
- Tatijana Zemunik,
- Erik van Iperen,
- Peter Kovacs,
- Nicholas D. Hastie,
- Sarah H. Wild,
- Stela McLachlan,
- Susan Campbell,
- Ozren Polasek,
- Olga Carlson,
- Josephine Egan,
- Wieland Kiess,
- Gonneke Willemsen,
- Johanna Kuusisto,
- Markku Laakso,
- Maria Dimitriou,
- Andrew A. Hicks,
- Rainer Rauramaa,
- Stefania Bandinelli,
- Barbara Thorand,
- Yongmei Liu,
- Iva Miljkovic,
- Lars Lind,
- Alex Doney,
- Markus Perola,
- Aroon Hingorani,
- Mika Kivimaki,
- Meena Kumari,
- Amanda J. Bennett,
- Christopher J. Groves,
- Christian Herder,
- Heikki A. Koistinen,
- Leena Kinnunen,
- Ulf de Faire,
- Stephan J. L. Bakker,
- Matti Uusitupa,
- Colin N. A. Palmer,
- J. Wouter Jukema,
- Naveed Sattar,
- Anneli Pouta,
- Harold Snieder,
- Eric Boerwinkle,
- James S. Pankow,
- Patrik K. Magnusson,
- Ulrika Krus,
- Chiara Scapoli,
- Eco J. C. N. de Geus,
- Matthias Blüher,
- Bruce H. R. Wolffenbuttel,
- Michael A. Province,
- Goncalo R. Abecasis,
- James B. Meigs,
- G. Kees Hovingh,
- Jaana Lindström,
- James F. Wilson,
- Alan F. Wright,
- George V. Dedoussis,
- Stefan R. Bornstein,
- Peter E. H. Schwarz,
- Anke Tönjes,
- Bernhard R. Winkelmann,
- Bernhard O. Boehm,
- Winfried März,
- Andres Metspalu,
- Jackie F. Price,
- Panos Deloukas,
- Antje Körner,
- Timo A. Lakka,
- Sirkka M. Keinanen-Kiukaanniemi,
- Timo E. Saaristo,
- Richard N. Bergman,
- Jaakko Tuomilehto,
- Nicholas J. Wareham,
- Claudia Langenberg,
- Satu Männistö,
- Paul W. Franks,
- Caroline Hayward,
- Veronique Vitart,
- Jaakko Kaprio,
- Sophie Visvikis-Siest,
- Beverley Balkau,
- David Altshuler,
- Igor Rudan,
- Michael Stumvoll,
- Harry Campbell,
- Cornelia M. van Duijn,
- Christian Gieger,
- Thomas Illig,
- Luigi Ferrucci,
- Nancy L. Pedersen,
- Peter P. Pramstaller,
- Michael Boehnke,
- Timothy M. Frayling,
- Alan R. Shuldiner,
- Patricia A. Peyser,
- Sharon L. R. Kardia,
- Lyle J. Palmer,
- Brenda W. Penninx,
- Pierre Meneton,
- Tamara B. Harris,
- Gerjan Navis,
- Pim van der Harst,
- George Davey Smith,
- Nita G. Forouhi,
- Ruth J. F. Loos,
- Veikko Salomaa,
- Nicole Soranzo,
- Dorret I. Boomsma,
- Leif Groop,
- Tiinamaija Tuomi,
- Albert Hofman,
- Patricia B. Munroe,
- Vilmundur Gudnason,
- David S. Siscovick,
- Hugh Watkins,
- Cecile Lecoeur,
- Peter Vollenweider,
- Anders Franco-Cereceda,
- Per Eriksson,
- Marjo-Riitta Jarvelin,
- Kari Stefansson,
- Anders Hamsten,
- George Nicholson,
- Fredrik Karpe,
- Emmanouil T. Dermitzakis,
- Cecilia M. Lindgren,
- Mark I. McCarthy,
- Philippe Froguel,
- Marika A. Kaakinen,
- Valeriya Lyssenko,
- Richard M. Watanabe,
- Erik Ingelsson,
- Jose C. Florez,
- Josée Dupuis,
- Inês Barroso,
- Andrew P. Morris,
- Inga Prokopenko,
- Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
Affiliations
- Vasiliki Lagou
- Wellcome Centre for Human Genetics, University of Oxford
- Reedik Mägi
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Jouke- Jan Hottenga
- Department of Biological Psychology, Vrije Universiteit
- Harald Grallert
- Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health
- John R. B. Perry
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Nabila Bouatia-Naji
- University of Lille Nord de France
- Letizia Marullo
- Department of Life Sciences and Biotechnology, University of Ferrara
- Denis Rybin
- Boston University Data Coordinating Center
- Rick Jansen
- Department of Psychiatry, VU University Medical Center
- Josine L. Min
- MRC Integrative Epidemiology Unit, University of Bristol
- Antigone S. Dimas
- Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming
- Anna Ulrich
- Department of Medicine, Imperial College London
- Liudmila Zudina
- Department of Medicine, Imperial College London
- Jesper R. Gådin
- Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital
- Longda Jiang
- Department of Medicine, Imperial College London
- Alessia Faggian
- Department of Medicine, Imperial College London
- Amélie Bonnefond
- University of Lille Nord de France
- Joao Fadista
- Department of Epidemiology Research, Statens Serum Institut
- Maria G. Stathopoulou
- Université de Lorraine, IGE-PCV
- Aaron Isaacs
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center
- Sara M. Willems
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center
- Pau Navarro
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Toshiko Tanaka
- Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging
- Anne U. Jackson
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- May E. Montasser
- Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine
- Jeff R. O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Rebecca J. Webster
- Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research
- Richa Saxena
- Broad Institute of Harvard and Massachusetts Institute of Technology (MIT)
- Jeanette M. Stafford
- Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine
- Beate St Pourcain
- MRC Integrative Epidemiology Unit, University of Bristol
- Nicholas J. Timpson
- MRC Integrative Epidemiology Unit, University of Bristol
- Perttu Salo
- Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare
- So-Youn Shin
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Najaf Amin
- Department of Epidemiology Erasmus MC
- Albert V. Smith
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Guo Li
- Cardiovascular Health Research Unit, University of Washington
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Anuj Goel
- Wellcome Centre for Human Genetics, University of Oxford
- Ian Ford
- Robertson Centre for Biostatistics, University of Glasgow
- Paul C. D. Johnson
- Robertson Centre for Biostatistics, University of Glasgow
- Toby Johnson
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Karen Kapur
- Department of Medical Genetics, University of Lausanne
- Gudmar Thorleifsson
- deCODE Genetics
- Rona J. Strawbridge
- Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet
- Laura J. Rasmussen-Torvik
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Tõnu Esko
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Evelin Mihailov
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Tove Fall
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Ross M. Fraser
- Usher Institute, University of Edinburgh
- Anubha Mahajan
- Wellcome Centre for Human Genetics, University of Oxford
- Stavroula Kanoni
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences, Uppsala Universitet
- Marcus E. Kleber
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Günther Silbernagel
- Division of Angiology, Department of Internal Medicine, Medical University of Graz
- Julia Meyer
- Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health
- Andrea Ganna
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Antti-Pekka Sarin
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki
- Loic Yengo
- University of Lille Nord de France
- Dmitry Shungin
- Department of Public Health & Clinical Medicine, Umeå University
- Jian’an Luan
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Momoko Horikoshi
- Wellcome Centre for Human Genetics, University of Oxford
- Ping An
- Division of Statistical Genomics, Washington University School of Medicine
- Serena Sanna
- Istituto di Ricerca Genetica e Biomedica, CNR
- Yvonne Boettcher
- Department of Medicine, University of Leipzig
- N. William Rayner
- Wellcome Centre for Human Genetics, University of Oxford
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Tatijana Zemunik
- Faculty of Medicine, University of Split
- Erik van Iperen
- Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam
- Peter Kovacs
- IFB AdiposityDiseases, University of Leipzig
- Nicholas D. Hastie
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Sarah H. Wild
- Usher Institute, University of Edinburgh
- Stela McLachlan
- Usher Institute, University of Edinburgh
- Susan Campbell
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Ozren Polasek
- Faculty of Medicine, University of Split
- Olga Carlson
- Laboratory of Clinical Investigation, National Institute of Aging
- Josephine Egan
- Laboratory of Clinical Investigation, National Institute of Aging
- Wieland Kiess
- IFB AdiposityDiseases, University of Leipzig
- Gonneke Willemsen
- Department of Biological Psychology, Vrije Universiteit
- Johanna Kuusisto
- Department of Medicine, University of Eastern Finland and Kuopio University Hospital
- Markku Laakso
- Department of Medicine, University of Eastern Finland and Kuopio University Hospital
- Maria Dimitriou
- Department of Dietetics-Nutrition, Harokopio University
- Andrew A. Hicks
- Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany)
- Rainer Rauramaa
- Kuopio Research Institute of Exercise Medicine
- Stefania Bandinelli
- Geriatric Unit, Azienda Sanitaria Firenze (ASF)
- Barbara Thorand
- German Center for Diabetes Research (DZD
- Yongmei Liu
- Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine
- Iva Miljkovic
- Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Alex Doney
- Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee
- Markus Perola
- Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare
- Aroon Hingorani
- Department of Epidemiology and Public Health, University College London
- Mika Kivimaki
- Department of Epidemiology and Public Health, University College London
- Meena Kumari
- Department of Epidemiology and Public Health, University College London
- Amanda J. Bennett
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Christopher J. Groves
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Christian Herder
- German Center for Diabetes Research (DZD
- Heikki A. Koistinen
- Department of Public Health Solutions, Finnish Institute for Health and Welfare
- Leena Kinnunen
- Department of Public Health Solutions, Finnish Institute for Health and Welfare
- Ulf de Faire
- Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Stephan J. L. Bakker
- Department of Internal Medicine, University of Groningen, University Medical Center Groningen
- Matti Uusitupa
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland
- Colin N. A. Palmer
- Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee
- J. Wouter Jukema
- Dept of Cardiology, Leiden University Medical Center
- Naveed Sattar
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Anneli Pouta
- Department of Government Services, Finnish Institute for Health and Welfare
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Eric Boerwinkle
- IMM Center for Human Genetics, University of Texas Health Science Center at Houston
- James S. Pankow
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Patrik K. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ulrika Krus
- Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University
- Chiara Scapoli
- Department of Life Sciences and Biotechnology, University of Ferrara
- Eco J. C. N. de Geus
- Department of Biological Psychology, Vrije Universiteit
- Matthias Blüher
- Department of Medicine, University of Leipzig
- Bruce H. R. Wolffenbuttel
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Michael A. Province
- Division of Statistical Genomics, Washington University School of Medicine
- Goncalo R. Abecasis
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- James B. Meigs
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- G. Kees Hovingh
- Department of Vascular Medicine, Amsterdam UMC
- Jaana Lindström
- Finnish Institute for Health and Welfare, Diabetes Prevention Unit
- James F. Wilson
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Alan F. Wright
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- George V. Dedoussis
- Department of Dietetics-Nutrition, Harokopio University
- Stefan R. Bornstein
- Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Peter E. H. Schwarz
- Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Anke Tönjes
- Department of Medicine, University of Leipzig
- Bernhard R. Winkelmann
- Cardiology Group
- Bernhard O. Boehm
- Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London
- Winfried März
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Andres Metspalu
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Jackie F. Price
- Usher Institute, University of Edinburgh
- Panos Deloukas
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Antje Körner
- IFB AdiposityDiseases, University of Leipzig
- Timo A. Lakka
- Kuopio Research Institute of Exercise Medicine
- Sirkka M. Keinanen-Kiukaanniemi
- Faculty of Medicine, Center for Life Course Health Research, University of Oulu
- Timo E. Saaristo
- Finnish Diabetes Association
- Richard N. Bergman
- Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center
- Jaakko Tuomilehto
- Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Satu Männistö
- Department of Public Health Solutions, Finnish Institute for Health and Welfare
- Paul W. Franks
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö
- Caroline Hayward
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Veronique Vitart
- MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Jaakko Kaprio
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki
- Sophie Visvikis-Siest
- Université de Lorraine, IGE-PCV
- Beverley Balkau
- Inserm, CESP Center for Research in Epidemiology and Public Health
- David Altshuler
- Broad Institute of Harvard and Massachusetts Institute of Technology (MIT)
- Igor Rudan
- Usher Institute, University of Edinburgh
- Michael Stumvoll
- Department of Medicine, University of Leipzig
- Harry Campbell
- Usher Institute, University of Edinburgh
- Cornelia M. van Duijn
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center
- Christian Gieger
- Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health
- Thomas Illig
- Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health
- Luigi Ferrucci
- Clinical Research Branch, National Institute on Aging
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Peter P. Pramstaller
- Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany)
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Timothy M. Frayling
- Genetics of Complex Traits, Peninsula Medical School, University of Exeter
- Alan R. Shuldiner
- Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Lyle J. Palmer
- School of Public Health, University of Adelaide
- Brenda W. Penninx
- Department of Psychiatry, VU University Medical Center
- Pierre Meneton
- U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers
- Tamara B. Harris
- Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging
- Gerjan Navis
- Department of Internal Medicine, University of Groningen, University Medical Center Groningen
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- George Davey Smith
- MRC Integrative Epidemiology Unit (IEU), University of Bristol
- Nita G. Forouhi
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Ruth J. F. Loos
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Veikko Salomaa
- Finnish Institute for Health and Welfare
- Nicole Soranzo
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Dorret I. Boomsma
- Department of Biological Psychology, Vrije Universiteit
- Leif Groop
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki
- Tiinamaija Tuomi
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki
- Albert Hofman
- Department of Epidemiology Erasmus MC
- Patricia B. Munroe
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Vilmundur Gudnason
- Icelandic Heart Association
- David S. Siscovick
- Cardiovascular Health Research Unit, University of Washington
- Hugh Watkins
- Wellcome Centre for Human Genetics, University of Oxford
- Cecile Lecoeur
- University of Lille Nord de France
- Peter Vollenweider
- Department of Medicine, University Hospital Lausanne
- Anders Franco-Cereceda
- Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet
- Per Eriksson
- Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London
- Kari Stefansson
- deCODE Genetics
- Anders Hamsten
- Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet
- George Nicholson
- Department of Statistics, University of Oxford
- Fredrik Karpe
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Emmanouil T. Dermitzakis
- Department of Genetic Medicine and Development, University of Geneva Medical School
- Cecilia M. Lindgren
- Wellcome Centre for Human Genetics, University of Oxford
- Mark I. McCarthy
- Wellcome Centre for Human Genetics, University of Oxford
- Philippe Froguel
- University of Lille Nord de France
- Marika A. Kaakinen
- Department of Medicine, Imperial College London
- Valeriya Lyssenko
- Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University
- Richard M. Watanabe
- Department of Preventive Medicine, Keck School of Medicine of USC
- Erik Ingelsson
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Jose C. Florez
- Center for Human Genetic Research, Massachusetts General Hospital
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- Inês Barroso
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Andrew P. Morris
- Wellcome Centre for Human Genetics, University of Oxford
- Inga Prokopenko
- Wellcome Centre for Human Genetics, University of Oxford
- Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
- DOI
- https://doi.org/10.1038/s41467-020-19366-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
