mBio (Feb 2021)
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
- Jenna J. Guthmiller,
- Olivia Stovicek,
- Jiaolong Wang,
- Siriruk Changrob,
- Lei Li,
- Peter Halfmann,
- Nai-Ying Zheng,
- Henry Utset,
- Christopher T. Stamper,
- Haley L. Dugan,
- William D. Miller,
- Min Huang,
- Ya-Nan Dai,
- Christopher A. Nelson,
- Paige D. Hall,
- Maud Jansen,
- Kumaran Shanmugarajah,
- Jessica S. Donington,
- Florian Krammer,
- Daved H. Fremont,
- Andrzej Joachimiak,
- Yoshihiro Kawaoka,
- Vera Tesic,
- Maria Lucia Madariaga,
- Patrick C. Wilson
Affiliations
- Jenna J. Guthmiller
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Olivia Stovicek
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Jiaolong Wang
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Siriruk Changrob
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Lei Li
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Peter Halfmann
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
- Nai-Ying Zheng
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Henry Utset
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Christopher T. Stamper
- Committee on Immunology, University of Chicago, Chicago, Illinois, USA
- Haley L. Dugan
- Committee on Immunology, University of Chicago, Chicago, Illinois, USA
- William D. Miller
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois, USA
- Min Huang
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- Ya-Nan Dai
- Department of Pathology and Immunology and Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, Washington University School of Medicine, St. Louis, Missouri, USA
- Christopher A. Nelson
- Department of Pathology and Immunology and Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, Washington University School of Medicine, St. Louis, Missouri, USA
- Paige D. Hall
- Department of Pathology and Immunology and Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, Washington University School of Medicine, St. Louis, Missouri, USA
- Maud Jansen
- Department of Medicine, University of Chicago, Chicago, Illinois, USA
- Kumaran Shanmugarajah
- Department of Surgery, University of Chicago, Chicago, Illinois, USA
- Jessica S. Donington
- Department of Surgery, University of Chicago, Chicago, Illinois, USA
- Florian Krammer
- ORCiD
- Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Daved H. Fremont
- Department of Pathology and Immunology and Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, Washington University School of Medicine, St. Louis, Missouri, USA
- Andrzej Joachimiak
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA
- Yoshihiro Kawaoka
- ORCiD
- Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
- Vera Tesic
- ORCiD
- Department of Pathology, University of Chicago, Chicago, Illinois, USA
- Maria Lucia Madariaga
- Department of Surgery, University of Chicago, Chicago, Illinois, USA
- Patrick C. Wilson
- ORCiD
- Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
- DOI
- https://doi.org/10.1128/mBio.02940-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein.
