Nature Communications (Aug 2022)

Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

  • Sabine M. Ulamec,
  • Roberto Maya-Martinez,
  • Emily J. Byrd,
  • Katherine M. Dewison,
  • Yong Xu,
  • Leon F. Willis,
  • Frank Sobott,
  • George R. Heath,
  • Patricija van Oosten Hawle,
  • Vladimir L. Buchman,
  • Sheena E. Radford,
  • David J. Brockwell

DOI
https://doi.org/10.1038/s41467-022-32687-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 38 is dependent on the amino-acid introduced, suggesting that specific interactions control α -Syn aggregation.