Communications Biology (Mar 2021)

Creb5 establishes the competence for Prg4 expression in articular cartilage

  • Cheng-Hai Zhang,
  • Yao Gao,
  • Unmesh Jadhav,
  • Han-Hwa Hung,
  • Kristina M. Holton,
  • Alan J. Grodzinsky,
  • Ramesh A. Shivdasani,
  • Andrew B. Lassar

DOI
https://doi.org/10.1038/s42003-021-01857-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 by TGFβ. These findings provide new insight into the molecular regulation of Prg4 expression in superficial zone articular chondrocytes.