Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs

Miguel Ganuza; Ashley Chabot; Xing Tang; Wenjian Bi; Sivaraman Natarajan; Robert Carter; Charles Gawad; Guolian Kang; Yong Cheng; Shannon McKinney-Freeman

doi:10.1038/s41467-018-07769-8

Nature Communications (Dec 2018)

Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs

Miguel Ganuza,
Ashley Chabot,
Xing Tang,
Wenjian Bi,
Sivaraman Natarajan,
Robert Carter,
Charles Gawad,
Guolian Kang,
Yong Cheng,
Shannon McKinney-Freeman

Affiliations

Miguel Ganuza: Department of Hematology, St. Jude Children’s Research Hospital
Ashley Chabot: Department of Hematology, St. Jude Children’s Research Hospital
Xing Tang: Department of Hematology, St. Jude Children’s Research Hospital
Wenjian Bi: Department of Biostatistics, St. Jude Children’s Research Hospital
Sivaraman Natarajan: Department of Oncology, St. Jude Children’s Research Hospital
Robert Carter: Department of Oncology, St. Jude Children’s Research Hospital
Charles Gawad: Department of Oncology, St. Jude Children’s Research Hospital
Guolian Kang: Department of Biostatistics, St. Jude Children’s Research Hospital
Yong Cheng: Department of Hematology, St. Jude Children’s Research Hospital
Shannon McKinney-Freeman: Department of Hematology, St. Jude Children’s Research Hospital

DOI: https://doi.org/10.1038/s41467-018-07769-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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The source of where definitive hematopoietic stem cells (dHSCs) develop in the mouse embyro has been much debated. Here, the authors identify that dHSCs arise from the intra-embyronic region by using murine embryonic explant transplantation but not from the yolk sac.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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