British Journal of Pharmacy (Jul 2018)

The Use Of XRPD And ATR-FTIR In The Screening Of Three Component Co-amorphous Systems Created Via A Melt-Quench Method

  • Benjamin Edgar,
  • Alessandra D'Angelo,
  • Milan D Antonjievic

DOI
https://doi.org/10.5920/bjpharm.2017.24
Journal volume & issue
Vol. 2, no. 2

Abstract

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Multiple three-component co-amorphous systems have been created via a melt- quench method. This has been confirmed by a single glass transition in the individual DSC traces and then reinforced by X-ray diffraction data, which show an absence of crystalline material. ATR-FTIR has also been used to show a change in bonding vibrations between the physical mixtures and co-amorphous samples. The change in bonding vibrations indicates different molecular interactions within the co-amorphous materials.

Keywords