Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea

Weijun Huang; Jingyu Zhang; Jianyin Zou; Xiaoting Wang; Huajun Xu; Jian Guan; Hongliang Yi; Suru Liu; Shankai Yin

iScience (Feb 2023)

Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea

Weijun Huang,
Jingyu Zhang,
Jianyin Zou,
Xiaoting Wang,
Huajun Xu,
Jian Guan,
Hongliang Yi,
Suru Liu,
Shankai Yin

Affiliations

Weijun Huang: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Jingyu Zhang: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Jianyin Zou: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Xiaoting Wang: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Huajun Xu: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Jian Guan: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China
Hongliang Yi: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China; Corresponding author
Suru Liu: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China; Corresponding author
Shankai Yin: Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai, China; Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China

Journal volume & issue: Vol. 26, no. 2
p. 105985

Abstract

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Summary: Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional and longitudinal analyses, the FGF21 level was associated with OSA. This analysis of two clinical cohorts is the first to show that the FGF21 level increased significantly with OSA severity and was an independent predictor of incident OSA in Chinese adults. The circulating FGF21 level could serve as a potential serum biomarker of OSA and its comorbidities and thus aid risk evaluation and early intervention.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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