Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors

• Derek J. Essegian,
• Tyler A. Cunningham,
• Christopher J. Zerio,
• Eli Chapman,
• Jonathan Schatz,
• Stephan C. Schürer

Affiliations

Derek J. Essegian

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, United States

Tyler A. Cunningham

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, United States

Christopher J. Zerio

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tuscon, Arizona, United States

Eli Chapman

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tuscon, Arizona, United States

Jonathan Schatz

Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, United States

Stephan C. Schürer

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, United States