Nature Communications (Jun 2019)

Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies

  • Rajkumar Dorajoo,
  • Xuling Chang,
  • Resham Lal Gurung,
  • Zheng Li,
  • Ling Wang,
  • Renwei Wang,
  • Kenneth B. Beckman,
  • Jennifer Adams-Haduch,
  • Yiamunaa M,
  • Sylvia Liu,
  • Wee Yang Meah,
  • Kar Seng Sim,
  • Su Chi Lim,
  • Yechiel Friedlander,
  • Jianjun Liu,
  • Rob M. van Dam,
  • Jian-Min Yuan,
  • Woon-Puay Koh,
  • Chiea Chuen Khor,
  • Chew-Kiat Heng

DOI
https://doi.org/10.1038/s41467-019-10443-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Shortening of leukocyte telomere length (LTL) is associated with age and increased risk for various chronic diseases. Here, the authors report genome-wide association studies for LTL in Singaporean Chinese populations and find that longer LTL associates with less severe outcomes of respiratory disease phenotypes.