Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration

Abstract

Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by stabilizing hemidesmosome attachment, preventing axon degeneration.