Life (Apr 2022)

Mango “Ataulfo” Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats

  • Alejandra M. Preciado-Saldaña,
  • Jesús Abraham Domínguez-Avila,
  • Jesús Fernando Ayala-Zavala,
  • Humberto F. Astiazaran-Garcia,
  • Marcelino Montiel-Herrera,
  • Mónica A. Villegas-Ochoa,
  • Gustavo A. González-Aguilar,
  • Abraham Wall-Medrano

DOI
https://doi.org/10.3390/life12040532
Journal volume & issue
Vol. 12, no. 4
p. 532

Abstract

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The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE.g−1) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.

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