Analysis of risk factors for lesion site of ischemic leukoaraiosis

Abstract

Objective To explore the related risk factors for ischemic leukoaraiosis (periventricular lesions and subcortical lesions). Methods A total of 127 patients with ischemic leukoaraiosis, including 78 patients with periventricular leukoaraiosis and 49 patients with coexisted periventricular and subcortical leukoaraiosis, were enrolled in this study. Fazekas classification was used to rate the severity of leukoaraiosis. Univariate and multivariate forward Logistic regression analysis were used to analyze and screen the related risk factors for ischemic leukoaraiosis. Results Logistic regression analysis showed age was independent risk factor for periventricular leukoaraiosis (OR = 1.103, 95%CI: 1.054-1.155; P = 0.000); age (OR = 1.154, 95%CI: 1.072-1.242; P = 0.000), hypertension (OR = 6.804, 95%CI: 1.793-25.825; P = 0.005) and prothrombin time (PT; OR = 2.418, 95% CI: 1.025-5.704, P = 0.044) were independent risk factors for periventricular and subcortical leukoaraiosis; age was independent risk factor for total periventricular leukoaraiosis (OR = 1.137, 95% CI: 1.064-1.216; P = 0.000). Conclusions Age was independent risk factor for periventricular leukoaraiosis; age, hypertension and PT were independent risk factors for periventricular and subcortical leukoaraiosis; age was independent risk factor for total periventricular leukoaraiosis. DOI: 10.3969/j.issn.1672-6731.2018.11.013

Keywords

• Leukoaraiosis
• Brain ischemia
• Risk factors
• Regression analysis