DEVELOPMENT OF IONIC CURRENT MODEL BASE FOR MEDICAL INFORMATION SYSTEM OF CARDIOVASCULAR DISEASES DIAGNOSTICS

Abstract

Background. Improving the quality of early cardiovascular disease diagnostics can be provided, among other things, by the introduction of medical information systems (MIS), which allow to collect and analyze information and to reduce the number of errors and improve the quality of diagnostics especially at early stages in the conditions of time deficit and available technical means of examination. According to the authors, such MIS should contain an extended base of ionic current models. Materials and methods. The article considers the Noble model, which can be used as a part of MIS for quantitative description of heart work processes in norm and at different pathologies and comparison of calculated values with the data of natural experiments. Results. The database of ionic currents containing the results of modeling of potassium, sodium, calcium currents, currents through sodium-potassium and sodium-calcium pumps, leakage currents, plateau and background currents was created. Conclusions. The availability the models of all components in the Noble equation will improve the accuracy of the MIS. If necessary, in the base of models it is possible to disable some sources to estimate the contribution of the corresponding components to the final sum of currents, as well as the methodological error arising if one or another component is neglected.

Keywords

• cardiovascular diseases
• medical information system
• model database
• ionic currents
• noble model
• transmembrane potential