Copper-catalyzed C(sp)-C(sp2) oxidative cross coupling reaction to access to methyl arylpropiolates at room temperature

Abstract

The first and environmentally benign oxidative cross coupling of stable trimethylsilylalkynoate with different arylboronic acids was developed. This reaction proceeded efficiently in the presence of Cu(OAc)2 ​at room temperature through the activation of Si–C bond by catalytic Cs2CO3, providing various methyl arylpropiolates in good yields with a broad substrate scope under mild conditions.

Keywords

• Oxidative cross coupling
• Copper catalysis
• Si–C bond Cleavage
• Pentacoordinate silane
• Cs2CO3 activation